4L液质联用甲醇

检测项目Test Items

指标要求Specifications

含量Assay CH₃OH(GC)

≥99.99

密度Density(20℃)

0.791～0.793

与水混合试验Solubility with H₂O

合格Pass test

蒸发残渣Residue on evaporation

≤0.0001

水分Water

≤0.01

酸度Acidity(as H⁺)

≤0.0002

碱度Alkalinity(as OH^-)

≤0.0001

吸光度Absorbance at 205 nm

≤1.0

吸光度Absorbance at 210 nm

≤0.45

吸光度Absorbance at 220 nm

≤0.20

吸光度Absorbance at 230 nm

≤0.10

吸光度Absorbance at 260 nm

≤0.01

梯度洗脱试验：254nm所有峰的吸光度

Gradient Elution Test

≤2

梯度洗脱试验：235nm所有峰的吸光度

Gradient Elution Test

≤2

荧光杂质Fluorescence impurityat 254 nm

≤1.0

荧光杂质Fluorescence impurity at 365 nm

≤0.5

LC-MS(正离子模式)以利血平计LC-MS(ESI⁺)

as reserpine

≤50

LC-MS(负离子模式)以4-硝基苯酚计LC-MS(ESI^-) as 4-nitrophenol

≤50

钾、银、钡、镉、钴、铬、铜、锰、镍、铅、锡(K、Ag、Ba、Cd、Co、Cr、Cu、Mn、Ni、Pb、Sn)

≤5

铝、钙、镁、铁Al、Ca、Mg、Fe

≤10

钠Na

≤100